Intravenous treatment of autoimmune hemolytic anemia with very high dose gammaglobulin Academic Article uri icon

Overview

MeSH Major

  • Anemia, Hemolytic, Autoimmune
  • gamma-Globulins

abstract

  • Autoimmune hemolytic anemia (AIHA) has been considered to be unresponsive to intravenous gammaglobulin (IVGG) at the doses that are effective in immune thrombocytopenic purpura and autoimmune neutropenia (usually 2 g/kg total dose). This study reports the use of a higher dose (5 g/kg total dose over 5 days) in four severe cases of AIHA which resulted in a sustained remission in two patients, a transient response in the third, and a failure in the forth patient. These data suggest that larger quantities of IVGG may be needed in this disease, possibly because the reticuloendothelial system appears to be enlarged in AIHA patients.

publication date

  • December 1986

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 2432727

Additional Document Info

start page

  • 264

end page

  • 9

volume

  • 51

number

  • 4