Motor neuron disease and plasma cell dysplasia Academic Article uri icon

Overview

MeSH Major

  • Amyotrophic Lateral Sclerosis
  • Motor Neurons
  • Muscular Atrophy
  • Paraproteinemias

abstract

  • In the years 1977 to 1984, 10 of 206 patients (4.8%) with motor neuron disease (MND) had M proteins; 4 had IgM and 6 had IgG. Among 100 control patients with other neurologic diseases, only 1 had an M protein. We later added six cases of MND and M proteins, as well as three with polyclonal IgM elevations and two with Bence-Jones proteins. Including other reports, there are now 37 known cases of MND with monoclonal and 5 with polyclonal gammopathy. There is evidence that plasma cell dyscrasia is often undetected; the actual incidence of serum immunoglobulin abnormality in patients with MND may be greater than our figure.

publication date

  • December 1986

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 3762961

Additional Document Info

start page

  • 1429

end page

  • 36

volume

  • 36

number

  • 11