Activated human monocytes express the c-sis proto-oncogene and release a mediator showing PDGF-like activity. Academic Article uri icon

Overview

MeSH

  • Gene Expression Regulation
  • Humans
  • Monokines
  • Phagocytes
  • Proteins

MeSH Major

  • Monocytes
  • Platelet-Derived Growth Factor
  • Proto-Oncogenes

abstract

  • Current ideas about the mechanism of wound healing and the pathogenesis of atherosclerosis, pulmonary fibrosis and hepatic fibrosis suggest a central role for the mononuclear phagocyte in attracting and/or stimulating the proliferation of mesenchymal cells. We demonstrate here that activated human blood monocytes, but not resting monocytes, release a mediator that attracts smooth muscle cells and cooperates with other mediators to stimulate fibroblast proliferation. This mediator is very similar to platelet-derived growth factor (PDGF): its chromatographic properties and chemical stability are similar to those of PDGF, it competes with 125I-PDGF for binding to fibroblasts and it immunoprecipitates with anti-PDGF antibodies. In parallel, stimulated monocytes, but not resting monocytes, express the c-sis proto-oncogene, a gene coding for one of the PDGF chains, consistent with the concept that expression of the c-sis proto-oncogene may be involved in the ability of mononuclear phagocytes to modulate the accumulation of mesenchymal cells.

publication date

  • January 9, 1986

has subject area

  • Gene Expression Regulation
  • Humans
  • Monocytes
  • Monokines
  • Phagocytes
  • Platelet-Derived Growth Factor
  • Proteins
  • Proto-Oncogenes

Research

keywords

  • Journal Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1038/319158a0

PubMed ID

  • 3941744

Additional Document Info

start page

  • 158

end page

  • 160

volume

  • 319

number

  • 6049