Analysis of T-cell receptor Beta Chain (T(β)) gene rearrangements demonstrates the monoclonal nature of T-cell chronic lymphoproliferative disorders Academic Article uri icon

Overview

MeSH Major

  • Leukemia, Lymphoid
  • Receptors, Antigen, T-Cell
  • Recombination, Genetic

abstract

  • We investigated the rearrangement patterns of the gene coding for the beta chain of the T cell receptor (T beta) in 11 patients with T-cell derived chronic lymphoproliferative disorders, including T-cell prolymphocytic leukemia (T-PLL) and T-cell chronic lymphocytic leukemia (T-CLL). We found that all five cases of T-PLL, and five of six cases of T-CLL, displayed T beta-gene rearrangements, clearly establishing their monoclonal nature. Clonality could not be determined in one case of T-CLL where the T beta gene was found unrearranged. Our results demonstrate that the majority of cases of both clinically aggressive T-PLL and clinically indolent T-CLL are monoclonal. These results suggest that the analysis of T beta gene rearrangements represents a valid tool for the differential diagnosis and clinical monitoring of T-cell derived chronic lymphoproliferative diseases.

publication date

  • June 3, 1986

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 3484426

Additional Document Info

start page

  • 247

end page

  • 50

volume

  • 67

number

  • 1