Pseudosarcomatous changes in inflammatory pseudopolyps of the colon Academic Article uri icon


MeSH Major

  • Colonic Neoplasms
  • Colonic Polyps
  • Fibroma


  • The occurrence of pseudomalignant changes in biopsy specimens from two patients with ulcerative colitis and pseudopolyposis is described. One lesion was characterized by the proliferation of large ganglion cell-like cells, similar to those observed in proliferative fasciitis. Ultrastructural and immunohistochemical findings supported a fibroblastic origin. Biopsy specimens of an inflammatory pseudopolyp from the second patient showed proliferation of oval to spindle cells that were initially interpreted as a possible neoplasm. The site of origin and reactive nature of this lesion became apparent on a subsequent polypectomy specimen. Attention is called to the occurrence of pseudosarcomatous changes in inflammatory pseudopolyps of the gastrointestinal tract that may lead to an erroneous diagnosis of malignancy.

publication date

  • November 19, 1986



  • Academic Article



  • eng

PubMed ID

  • 3755892

Additional Document Info

start page

  • 833

end page

  • 6


  • 110


  • 9