A comparison of conjunctival and nonocular dendritic cells utilizing new monoclonal antibodies Academic Article uri icon

Overview

MeSH Major

  • Antibodies, Monoclonal
  • Conjunctiva
  • Dendritic Cells

abstract

  • Langerhans cells belong to the dendritic cell family. Their presence in the conjunctiva and cornea has been demonstrated by means of various membrane and cytoplasmic markers. Utilizing OKT6, a monoclonal antibody that specifically binds to Langerhans cells in conjunction with la histocompatibility antigens (HLA-DR), and a new panel of monoclonal antibodies, we compared the population density and characteristic phenotypes of Langerhans cells in normal conjunctiva with those in normal epidermis. A greater density of Langerhans cells was noted in epidermis in comparison with conjunctiva. Various areas of the conjunctiva and cornea were mapped for Langerhans cell distribution. The T6/la ratio of Langerhans cells in conjunctiva was notably different from that in skin. Utilizing the Prolm2 marker, we identified non-Langerhans dendritic cells in the substantia propria and in the basilar epithelium of the conjunctiva, antigen-processing cells probably identical to the interdigitating dendritic cells of lymph nodes.

publication date

  • November 12, 1986

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 3763159

Additional Document Info

start page

  • 1089

end page

  • 97

volume

  • 93

number

  • 8