Calcium antagonist receptors in cardiomyopathic hamster: Selective increases in heart, muscle, brain Academic Article uri icon

Overview

MeSH Major

  • Brain Chemistry
  • Cardiomyopathy, Hypertrophic
  • Muscles
  • Myocardium
  • Receptors, Nicotinic

abstract

  • The Syrian cardiomyopathic hamster has a hereditary disease in which a progressive myocardial necrosis mimics human forms of cardiac hypertrophy. Lesions are associated with calcium overload and can be prevented with the calcium antagonist verapamil. Numbers of receptor binding sites for calcium antagonists in heart, brain, skeletal muscle, and smooth muscle were markedly increased in cardiomyopathic hamsters. The uptake of calcium-45 into brain synaptosomes was also increased in cardiomyopathic hamsters. The increase in calcium antagonist receptors and related voltage-sensitive calcium channels may be involved in the pathogenesis of this cardiomyopathy.

publication date

  • December 1986

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 3008330

Additional Document Info

start page

  • 515

end page

  • 8

volume

  • 232

number

  • 4749