Prostaglandin release by the chick embryo heart is increased by 2,3,7,8-tetrachlorodibenzo-p-dioxin and by other cytochrome P-448 inducers Academic Article Article uri icon


MeSH Major

  • Antidepressive Agents
  • Anxiety Disorders
  • Cycloserine
  • Excitatory Amino Acid Agonists
  • Implosive Therapy
  • N-Methylaspartate
  • Obsessive-Compulsive Disorder
  • Outcome Assessment (Health Care)
  • Stress Disorders, Post-Traumatic


  • Exposure of chick embryos in ovo to cytochrome P-448 inducers 2,3,7,8-tetrachlorodibenzo-p-dioxin, 3,4,3',4'-tetrachlorobiphenyl, 3,4,5,3',4',5'-hexachlorobiphenyl and beta-napthoflavone, increased cardiac prostaglandins in vitro. The dose response relationships were biphasic with prostaglandin release increasing at the low doses and returning to basal levels at higher doses. Phenobarbital was ineffective. Increased cardiac prostaglandin release was detected at doses that induced hepatic 7-ethoxyresorufin deethylase (7-ER) but which were below the threshold for cardiac induction. The fall in prostaglandin release coincided with induction of cardiac 7-ER and therefore may be attributable to increased prostaglandin metabolism. These studies show that the P-450 system may interact with the arachidonic acid metabolizing system to increase PG release and that this effect may be part of the pleiotypic response to Ah-receptor activation.

publication date

  • April 29, 1986



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1016/0006-291X(86)90480-8

PubMed ID

  • 3085671

Additional Document Info

start page

  • 582

end page

  • 9


  • 136


  • 2