A randomized clinical trial of oral ursodeoxycholic acid in obstructive jaundice Academic Article Article uri icon


MeSH Major

  • Echocardiography
  • Mitral Valve Insufficiency
  • Ultrasonography, Doppler


  • Forty patients with obstructive jaundice (bilirubin greater than 100 mumol/l) were entered into a randomized trial of oral ursodeoxycholic acid for 48 h before surgery versus no additional therapy. Pre-operative venous and operative portal total bile salt concentrations were higher in the bile salt treated patients (P less than 0.001). Portal endotoxaemia during operation was reduced in ursodeoxycholic acid treated patients (P less than 0.05). There was no significant difference in systemic venous endotoxaemia, renal function or postoperative morbidity or mortality. This study suggests pre-operative oral bile salt therapy may be of no clinical benefit in patients with obstructive jaundice.

publication date

  • January 1986



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1002/bjs.1800730819

PubMed ID

  • 3527321

Additional Document Info

start page

  • 634

end page

  • 6


  • 73


  • 8