Decreased biliary excretion of piperacillin after percutaneous relief of extrahepatic obstructive jaundice Academic Article uri icon


MeSH Major

  • Bile
  • Cholestasis, Extrahepatic
  • Piperacillin


  • The biliary excretion of piperacillin has been assessed in 11 patients with obstructive jaundice due to hilar cholangiocarcinoma. After a 1-g intravenous dose administered 30 min before preliminary percutaneous transhepatic cholangiography, no drug was detected in the bile of seven patients; in four others, drug concentrations were far below the corresponding level in serum. After a period of external biliary drainage of up to 28 days, levels of antibiotic in bile after intravenous administration were only minimally increased. The results suggest that although the impairment of hepatic function may be improved by external biliary decompression when assessed by a fall in plasma bilirubin, the biliary elimination of piperacillin and related beta-lactam antibiotics may remain impaired for prolonged periods.

publication date

  • December 1985



  • Academic Article



  • eng

PubMed Central ID

  • PMC180327

PubMed ID

  • 4083861

Additional Document Info

start page

  • 778

end page

  • 80


  • 28


  • 6