Lymphoid tumors displaying rearrangements of both immunoglobulin and T cell receptor genes Academic Article uri icon

Overview

MeSH Major

  • Leukemia
  • Lymphoma
  • Receptors, Antigen, T-Cell
  • Receptors, Immunologic

abstract

  • Ig and T beta gene rearrangements can be used as genetic markers of lineage and clonality in the study of B and T cell populations. We have addressed the issue of the respective B and T lineage specificity of these rearrangements by analyzing a panel of 63 lymphoid tumors representative of the various clinicopathologic categories of both B and T neoplasias. We report that approximately 10% of the cases tested displayed rearrangements of both Ig and T beta genes. Despite their dual genotypic pattern, these tumors retain a pure immunophenotype, i.e. they display either B or T cell lineage-restricted cell surface antigens. The implications of these findings for both normal and neoplastic lymphoid differentiation are discussed.

publication date

  • December 1985

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2187802

PubMed ID

  • 3875679

Additional Document Info

start page

  • 1015

end page

  • 24

volume

  • 162

number

  • 3