Follicular bronchiolitis in association with connective tissue diseases Academic Article Article uri icon


MeSH Major

  • AIDS-Related Opportunistic Infections
  • Antiretroviral Therapy, Highly Active
  • Systemic Inflammatory Response Syndrome


  • Eleven patients with connective tissue diseases were found to have bronchiolar lesions associated with minimal or no alveolar septal thickening. Seven of these patients had rheumatoid arthritis, 3 had Sjögren's syndrome, and 1 had ankylosing spondylitis. Radiographic studies showed an interstitial pattern in all patients. The patients were nonsmokers and received no treatment prior to biopsy. All lung biopsy specimens showed inflammatory bronchiolar lesions which consisted of bronchiolar and peribronchiolar lymphocytic infiltrates (follicular bronchiolitis). The bronchiolar lesion has been reported previously in patients with connective tissue diseases treated with D-penicillamine; whether it represents a component of the systemic disease or a lack of effect of the therapeutic agent had not been established. The present study shows that several connective tissue diseases can be associated with inflammatory bronchiolar lesions. © 1985 Springer-Verlag New York, Inc.

publication date

  • December 1985



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1007/BF02713828

PubMed ID

  • 3934469

Additional Document Info

start page

  • 305

end page

  • 14


  • 163


  • 1