Selective sparing of a class of striatal neurons in Huntington's disease Academic Article Article uri icon


MeSH Major

  • Huntington Disease
  • Nerve Tissue Proteins
  • Nuclear Proteins


  • A distinct subpopulation of striatal aspiny neurons, containing the enzyme nicotinamide adenine dinucleotide phosphate diaphorase, is preserved in the caudate nucleus in Huntington's disease. Biochemical assays confirmed a significant increase in the activity of this enzyme in both the caudate nucleus and putamen in postmortem brain tissue from patients with this disease. The resistance of these neurons suggests that the gene defect in Huntington's disease may be modifiable by the local biochemical environment. This finding may provide insight into the nature of the genetically programmed cell death that is a characteristic of the disease.

publication date

  • December 1985



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1126/science.2931802

PubMed ID

  • 2931802

Additional Document Info

start page

  • 561

end page

  • 3


  • 230


  • 4725