Treatment of cytomegalovirus retinitis with 9-[2-hydroxy-1-(hydroxymethyl)ethoxymethyl] guanine Academic Article uri icon

Overview

MeSH Major

  • Acyclovir
  • Antiviral Agents
  • Cytomegalovirus Infections
  • Retinitis

abstract

  • Cytomegalovirus infections can cause significant morbidity and mortality in immunosuppressed patients, and present antiviral agents have had little efficacy against these infections. We describe the use of an acyclic nucleoside 9-[2-hydroxy-1-(hydroxymethyl) ethoxy methyl]guanine (BW B759U), in the treatment of two patients with cytomegalovirus retinitis. The efficacy of this agent was evident, with healing of retinal lesions and resolution of viremia and viral shedding. BW B759U appears to be similar pharmacokinetically to intravenous acyclovir in terms of half-life, peak serum levels, and renal excretion.

publication date

  • December 4, 1985

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 2992334

Additional Document Info

start page

  • 377

end page

  • 80

volume

  • 103

number

  • 3