Isolation of lymphadenopathy-associated virus (LAV) and detection of LAV antibodies from US patients with AIDS Academic Article Article uri icon


MeSH Major

  • Multiple Sclerosis


  • A human retrovirus was isolated from the peripheral blood of three American patients newly diagnosed with the acquired immunodeficiency syndrome (AIDS). In each case the major core viral protein (p25) was shown to be antigenically identical to that of the prototype lymphadenopathy-associated virus (LAV). Two of the viral isolates were derived from intravenous narcotics abusers, the first demonstration of LAV isolation from this risk group. Antibody to LAV was detected by an IgG enzyme-linked immunosorbent assay in the serum samples of these and 14 additional American patients with AIDS and in none of 12 hospital worker controls. These findings provide support for the etiologic association of LAV and AIDS.

publication date

  • May 14, 1985



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1001/jama.253.12.1737

PubMed ID

  • 2983130

Additional Document Info

start page

  • 1737

end page

  • 9


  • 253


  • 12