Monozygotic siblings discordant for neuroblastoma: Etiologic implications Academic Article Article uri icon

Overview

MeSH Major

  • 3-Iodobenzylguanidine
  • Neuroblastoma
  • Radiopharmaceuticals

abstract

  • Although rarely reported, neuroblastoma in monozygotic siblings merits attention because study of its features may aid in elucidating mechanisms of tumorigenesis. We describe disseminated neuroblastoma in one of monozygotic triplets, including both documentation of monozygosity and long-term follow-up of the unaffected co-twins. Information from reports of monozygotic twins concordant and discordant for neuroblastoma reinforces the hypothesis that hereditary factors may be predominant in neuroblastoma diagnosed in infants, whereas nonheritable random mutational genetic events may be more important in neuroblastoma diagnosed after infancy.

publication date

  • January 1985

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/S0022-3476(85)80515-1

PubMed ID

  • 4040963

Additional Document Info

start page

  • 405

end page

  • 9

volume

  • 107

number

  • 3