A distinctive cutaneous malignant neoplasm expressing the Langerhans cell phenotype. Synchronous occurrence with B-chronic lymphocytic leukemia Academic Article Article uri icon


MeSH Major

  • DNA-Binding Proteins
  • Lymphoma, B-Cell
  • Lymphoma, Large B-Cell, Diffuse
  • Mutation, Missense
  • Nuclear Proteins
  • Transcription Factors


  • The authors describe a 63-year-old woman who developed a histologically distinctive malignant cutaneous neoplasm composed of large pleomorphic cells with abundant cytoplasm and multilobate, often clefted nuclei that occasionally contained small nucleoli. This neoplastic cell population metastasized to a regional lymph node already involved by a B-cell derived chronic lymphocytic leukemia expressing surface IgMk, BA-1, and OKT1. The large metastatic tumor cells lacked surface immunoglobulin, B-lymphocyte associated antigen BA-1, T-lymphocyte associated antigens OKT1 and OKT3, and the monocyte/macrophage markers lysozyme and alpha 1-antichymotrypsin. These tumor cells expressed HLA-DR antigens, adenosine triphosphatase (ATPase), OKT6, and contained S-100 protein, i.e., they expressed the phenotype peculiar to epidermal Langerhans cells. The typical clinical and histologic features of Histiocytosis X were absent. Thus, this case appears to represent a distinctive cutaneous neoplasm composed entirely of malignant cells of dendritic cell origin which, by immunophenotypic and histochemical analysis, appear to be related to epidermal Langerhans cells.

publication date

  • July 4, 1985



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1002/1097-0142(19850515)55:10<2417::AID-CNCR2820551020>3.0.CO;2-9

PubMed ID

  • 3886125

Additional Document Info

start page

  • 2417

end page

  • 25


  • 55


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