Ganglioside GD2 specificity of monoclonal antibodies to human neuroblastoma cell Academic Article Article uri icon

Overview

MeSH Major

  • Immunity, Innate
  • Interleukin-17
  • Lymphocytes
  • Multipotent Stem Cells

abstract

  • Four monoclonal antibodies (3F8, 3A7, 3G6, and 2F7) against human neuroblastoma cells have been suggested to react with surface glycolipids of these cells. In this report these monoclonal antibodies were shown to be specific to the disialoganglioside GD2 using a thin-layer chromatography (TLC)-immunostaining method. When mixed human brain gangliosides were developed by TLC in two different solvent systems and incubated with each of the monoclonal antibodies, only GD2 was stained. These antibodies also reacted with highly purified GD2 on the plate. These findings suggest that GD2 provides an antigenic site on the surface of human neuroblastoma cells.

publication date

  • February 28, 1985

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/S0006-291X(85)80117-0

PubMed ID

  • 2579648

Additional Document Info

start page

  • 1

end page

  • 7

volume

  • 127

number

  • 1