Terminal deoxynucleotidyl transferase activity in childhood leukemia. Academic Article uri icon

Overview

MeSH

  • Acute Disease
  • Adolescent
  • Bone Marrow
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Male
  • Prognosis
  • Time Factors

MeSH Major

  • DNA Nucleotidylexotransferase
  • DNA Nucleotidyltransferases
  • Leukemia

abstract

  • The activity of terminal deoxynucleotidyl transferase (Tdt) was measured in mononuclear cells of 70 children with acute leukemia, in whom raised levels of Tdt were noted at diagnosis, relapse, or during remission. Serial measurements of Tdt activity were related to the percentage of blasts in the bone marrow and the clinical course of children both during therapy and after its completion. The Tdt values did not predict relapse in children with acute lymphoblastic leukemia nor did the quantitative determination correlate with the percentage of blasts in the bone marrow.

publication date

  • May 1, 1985

has subject area

  • Acute Disease
  • Adolescent
  • Bone Marrow
  • Child
  • Child, Preschool
  • DNA Nucleotidylexotransferase
  • DNA Nucleotidyltransferases
  • Female
  • Humans
  • Infant
  • Leukemia
  • Male
  • Prognosis
  • Time Factors

Research

keywords

  • Journal Article

Identity

Language

  • eng

PubMed ID

  • 3978575

Additional Document Info

start page

  • 1943

end page

  • 1947

volume

  • 55

number

  • 9