Phase II trial of elliptinium in advanced renal cell carcinoma and carcinoma of the breast
Academic Article
Overview
MeSH Major
Adenocarcinoma
Alkaloids
Antineoplastic Agents
Breast Neoplasms
Ellipticines
Kidney Neoplasms
abstract
Elliptinium, 100 mg/m2 i.v. weekly, was administered to 14 patients with advanced renal cancer and 4 with breast cancer. There were no responses in 11 adequately treated patients. An unexpectedly high incidence of xerostomia, allergic, and hemolytic reactions were observed, which resulted in cessation of the trial. Recent data suggest polymer formation occurs with reconstituted elliptinium, and further trials are warranted when a new formulation is available.