CSF monoamine metabolites in movement disorders and normal aging Academic Article uri icon

Overview

MeSH Major

  • 3,4-Dihydroxyphenylacetic Acid
  • Dyskinesia, Drug-Induced
  • Dystonia
  • Glycols
  • Homovanillic Acid
  • Hydroxyindoleacetic Acid
  • Methoxyhydroxyphenylglycol
  • Parkinson Disease
  • Phenylacetates

abstract

  • We measured four monoamine metabolite levels in CSF before and after probenecid administration to normal controls and to patients with Huntington's disease (HD), dystonia, and tardive dyskinesia. We identified differences only for the dopamine metabolite homovanillic acid (HVA), which showed increased baseline values and decreased turnover in normal aging, but decreased baseline values and normal turnover in HD. These results suggest that dopamine neurons are linked both to normal aging and to HD and that CSF HVA studies can distinguish differences in the functioning of dopamine neurons in normal aging and HD.

publication date

  • January 1985

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 2579626

Additional Document Info

start page

  • 166

end page

  • 9

volume

  • 42

number

  • 2