Immunologivcal abnormalities in thalassaemia major. I. A transfusion-related increase in circulating cytoplasmic immunoglobulin-positive cells Academic Article uri icon


MeSH Major

  • B-Lymphocytes
  • Blood Transfusion
  • Immunoglobulins
  • Thalassemia


  • Multiply transfused patients with beta-thalassaemia major have elevated serum immunoglobulin levels and a transfusion-related increase in (T8+) T-suppressor cells. We report here that these patients also have a significantly increased (P less than 0.001) proportion of B-cells that contain cytoplasmic immunoglobulin when visualized immediately upon isolation. On the other hand, the same cell populations do not exhibit an increase in the proportion of immunoglobulin-secreting cells as measured by a reverse haemolytic plaque assay. These results, together with those of ongoing studies, suggest that the cells containing the cytoplasmic immunoglobulin are likely to be terminally differentiated B-cells which persist in the circulation. While the reason for this phenomenon is not yet known, we have found that the increase in these cells is transfusion-related.

publication date

  • January 1985



  • Academic Article



  • eng

PubMed Central ID

  • PMC1577434

PubMed ID

  • 3878749

Additional Document Info

start page

  • 397

end page

  • 404


  • 62


  • 2