Control of primary osteosarcoma with chemotherapy Academic Article Article uri icon


MeSH Major

  • Databases, Factual
  • Information Storage and Retrieval
  • Medicine
  • Natural Language Processing
  • Specialization
  • Vocabulary, Controlled


  • High-dose methotrexate with citrovorum factor "rescue" (MTX-CF) produced an apparent complete response of the primary tumor in three patients with osteosarcoma. The response was sustained with MTX-CF, intra-arterial cis-diamminedichloroplatinum II (CDP) and Adriamycin (doxorubicin) for 18 months. Treatment was then electively discontinued. Local recurrence occurred in two patients, 6 and 4 months later, respectively. MTX-CF was reinstated and a complete response was again achieved in one patient. This has been maintained for 15+ months with MTX-CF and intra-arterial CDP administered for 13 of the 15+ months. Reinduction with MTX-CF failed in the second relapsed patient but an apparent remission was again achieved with radiation and intra-arterial CDP. This has been maintained with intravenous CDP, cyclophosphamide and phenylalanine mustard for 14+ months. A complete response in the primary tumor was still present in the nonrelapsed patient, 42 months from diagnosis. All patients have remained free of pulmonary metastases, 40+ to 42+ months from diagnosis.

publication date

  • January 1985



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1002/1097-0142(19850801)56:3<461::AID-CNCR2820560308>3.0.CO;2-L

PubMed ID

  • 3873985

Additional Document Info

start page

  • 461

end page

  • 6


  • 56


  • 3