The Response of Fibronectin to Differing Parenteral Caloric Sources in Normal Man Academic Article uri icon


MeSH Major

  • Fibronectins
  • Protein-Energy Malnutrition


  • The relationship between circulating fibronectin concentration and nutritional status was examined in eight healthy male (31 +/- 1 yr old) volunteers in three nutritional states: the postabsorptive state, after 10 days of protein-caloric starvation, and during the 10th day of refeeding by total parenteral nutrition. Plasma fibronectin was significantly decreased from 330 +/- 22 to 154 +/- 11 micrograms/ml (p less than 0.001) from the postabsorptive to starved state which was accompanied by appropriate changes in body weight, anthropometric measurements, and nitrogen balance. Plasma fibronectin levels were restored to 402 +/- 39 micrograms/ml following 10 days of total parenteral nutrition. The plasma fibronectin response was greater (p less than 0.05) during total parenteral nutrition with dextrose as the nonprotein calorie source as compared to a 50% dextrose/50% lipid regimen. These results suggest that the calorie source must be considered during interpretation of plasma fibronectin levels in patients undergoing parenteral nutrition.

publication date

  • January 1985



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1177/0148607185009004435

PubMed ID

  • 3928916

Additional Document Info

start page

  • 435

end page

  • 8


  • 9


  • 4