Transient, Marked, Unexplained Elevation of Serum Alkaline Phosphatase Academic Article Article uri icon


MeSH Major

  • Depression
  • Schizophrenia


  • Five children, aged 16 to 38 months, were found to have serum alkaline phosphatase levels seven to 30 times the upper limit of the reference range. Studies suggested a skeletal origin for the enzyme. No other abnormalities or explanations for the unusual enzyme levels were found. The enzyme levels returned to the reference range. A retrospective review of the records of 74 children with lymphoblastic leukemia, who were 2 to 4 years of age at diagnosis, disclosed only four cases of transient, isolated serum alkaline phosphatase elevation similar in degree to those described herein. The review covered 661 patient-years follow-up and 2,417 enzyme measurements. Benign, transient hyperphosphatasemia is a rarely recognized clinical entity. Awareness of this condition should curtail the extensive evaluation that may follow the detection of such an abnormality.

publication date

  • December 21, 1984



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1001/jama.1984.03350230049033

PubMed ID

  • 6595423

Additional Document Info

start page

  • 3289

end page

  • 92


  • 252


  • 23