Phase II trial of 10-deazaaminopterin for advanced hypernephroma Academic Article uri icon

Overview

MeSH Major

  • Aminopterin
  • Carcinoma, Renal Cell
  • Folic Acid Antagonists
  • Kidney Neoplasms

abstract

  • 10-Deazaaminopterin, a derivative of aminopterin with enhanced cellular uptake relative to methotrexate, was given to fourteen patients with advanced measurable hypernephroma. The dose-limiting toxicity was mucositis. Abnormalities in liver function were seen in 8 patients. No responses were seen in 13 adequately treated patients including 10 who had received no prior chemotherapy. The unique transport of this new group of compounds is discussed.

publication date

  • December 1984

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 6517533

Additional Document Info

start page

  • 409

end page

  • 10

volume

  • 4

number

  • 6