The effect of indomethacin on the duration of the hypotensive action of bradykinin in Dahl salt-resistant rats: Role of cyclooxygenase inhibition Academic Article Article uri icon

Overview

MeSH Major

  • Cardiovascular Diseases
  • MicroRNAs

abstract

  • The Dahl salt resistant (DR) rat maintained on a low, 0.4%, or a high 8.0% salt-diet remained normotensive. The bradykinin (BK) induced falls in the systolic (SBP) and diastolic (DBP) were unaffected (P greater than 0.05) by the presence of indomethacin (5 mg/kg). Indomethacin, however, caused a substantial (P less than 0.001) reduction in the duration of the hypotensive action of bradykinin. It is speculated that the indomethacin effects result from an inhibition of the cyclooxygenase system in DR rats.

publication date

  • January 1984

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/0262-1746(84)90031-3

PubMed ID

  • 6427790

Additional Document Info

start page

  • 131

end page

  • 5

volume

  • 14

number

  • 1