Neuropathy and anti-MAG antibodies without detectable serum M-protein Academic Article uri icon

Overview

MeSH Major

  • Antibodies, Anti-Idiotypic
  • Blood Proteins
  • Myelin Proteins
  • Peripheral Nervous System Diseases

abstract

  • Anti-MAG IgM antibodies were detected by ELISA in a patient with slowly progressive peripheral neuropathy. Serum IgM content was normal, and no M-protein was detected by serum protein electrophoresis, immunoelectrophoresis, or immunostaining. By immunoblot analysis, the anti-MAG antibodies were IgMk; they reacted with human and bovine MAG but not with mouse MAG. The data suggest that there was an anti-MAG IgM M-protein in concentration too low to be detected by conventional techniques. Tests for anti-MAG antibodies should be done in patients with slowly progressive neuropathy of unknown etiology, even in the absence of detectable serum M-protein.

publication date

  • March 30, 1984

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 6198602

Additional Document Info

start page

  • 218

end page

  • 21

volume

  • 34

number

  • 2