Intraocular injection of tetrodotoxin in goldfish decreases fast axonal transport of [3H]glucosamine-labeled materials in optic axons Academic Article Article uri icon

Overview

MeSH Major

  • Nerve Regeneration
  • Optic Nerve
  • Proteins

abstract

  • When physiological activity in goldfish visual system was abolished by repeated intraocular injection of tetrodotoxin (TTX), the fast axonal transport of radioactive amino acid-labeled protein in the optic axons was unaltered. However, the TTX treatment reduced the amount of [3H]glucosamine-labeled glycolipids that were axonally transported to the optic tectum, and may have decreased their rate of turnover in the tectum. A similar though smaller effect was observed for glucosamine-containing glycoproteins. These alterations in axonal transport may be the basis for at least some of the deleterious effects of TTX on axonal regeneration in this system.

publication date

  • May 7, 1984

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(84)90807-2

PubMed ID

  • 6202373

Additional Document Info

start page

  • 190

end page

  • 4

volume

  • 299

number

  • 1