Immunologic inhibition of ultraviolet radiation-induced tumor suppressor cell activity Academic Article uri icon

Overview

MeSH Major

  • T-Lymphocytes, Regulatory

abstract

  • Long-term exposure of C3H mice to ultraviolet radiation resulted in the formation of suppressor T cells that recognize ultraviolet radiation-induced regressor skin cancers as a class before the appearance of overt tumors. Administration of monoclonal antibodies to the product of the I-Jk subregion of the major histocompatibility complex or low doses of cyclophosphamide in vivo inhibited the development or activity of these cells. This activity of the monoclonal antibody was eliminated by adsorption on B10.BR (I-Jk) but not B10.D2 (I-Jd) splenocytes. These findings provide evidence that elements expressing the I-J determinant are important in regulating the host response prior to the overt development of ultraviolet radiation-induced skin cancers and suggest novel therapeutic approaches to malignancies or other diseases involving suppressor T cells in their pathogenesis.

publication date

  • December 1984

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 6231725

Additional Document Info

start page

  • 615

end page

  • 7

volume

  • 224

number

  • 4649