Chaotic behavior in dopamine neurodynamics Academic Article uri icon

Overview

MeSH Major

  • Brain
  • Dopamine
  • Schizophrenia

abstract

  • We report the results of the dynamics of a model of the central dopaminergic neuronal system. In particular, for certain values of a parameter k, which monitors the efficacy of dopamine at the postsynaptic receptor, chaotic solutions of the dynamical equations appear--a prediction that correlates with the observed increased variability in behavior among schizophrenics, the rapid fluctuations in motor activity among Parkinsonian patients treated chronically with L-dopa, and the lability of mood in some patients with an affective disorder. Moreover our hypothesis offers specific results concerning the appearance or disappearance of erratic solutions as a function of k and the external input to the dopamine neuronal system.

publication date

  • January 1984

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC344803

PubMed ID

  • 6583705

Additional Document Info

start page

  • 1244

end page

  • 7

volume

  • 81

number

  • 4 I