Scintigraphy of normal mouse ovaries with monoclonal antibodies to ZP-2, the major zona pellucida protein Academic Article uri icon

Overview

MeSH Major

  • Antibodies, Monoclonal
  • Egg Proteins
  • Glycoproteins
  • Membrane Glycoproteins
  • Ovary
  • Ovum
  • Receptors, Cell Surface
  • Zona Pellucida

abstract

  • The zona pellucida is an extracellular glycocalyx, made of three sulfated glycoproteins, that surrounds mammalian oocytes. Parenterally administered monoclonal antibodies specific for ZP-2, the most abundant zona protein, localize in the zona pellucida. When labeled with iodine-125, these monoclonal antibodies demonstrate a remarkably high target-to-nontarget tissue ratio and provide clear external radioimaging of ovarian tissue.

publication date

  • January 1984

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 6474160

Additional Document Info

start page

  • 938

end page

  • 41

volume

  • 225

number

  • 4665