Leukemia following treatment of germ cell tumors in man Academic Article uri icon


MeSH Major

  • Leukemia
  • Neoplasms, Germ Cell and Embryonal
  • Testicular Neoplasms


  • We investigated the incidence of leukemia occurring subsequent to the treatment of germ cell tumors in men at our institution over a 30-year interval and found four patients with acute nonlymphocytic leukemia (ANLL) and one patient with chronic myelomonocytic leukemia. The relative risk (observed/expected cases) estimates for the development of leukemia ranged from 13.7 (P = .0005) in the total population to 50.1 (P = .0001) in the group treated with cytotoxic agents alone. All three patients with ANLL treated with contemporary antileukemic therapy had complete responses, with survivals of 7, 29, and 133 + months. In a review of the literature, 14 additional cases of germ cell tumors were found in which the men subsequently developed leukemia. It is concluded that leukemia following germ cell tumors is increased in incidence and is likely to be treatment induced. Complete responses and long-term survival are possible in secondary leukemia and aggressive antileukemic therapy should be given.

publication date

  • December 19, 1984



  • Academic Article



  • eng

PubMed ID

  • 6092549

Additional Document Info

start page

  • 1080

end page

  • 7


  • 2


  • 10