Antigrowth effect of polyamine biosynthesis inhibitors on the dunning R 3327‐G prostatic tumor Academic Article Article uri icon

Overview

MeSH Major

  • Cystadenocarcinoma
  • Prostatic Neoplasms

abstract

  • alpha-Difluoromethylornithine (DFMO) and methylglyoxal-bis-guanylhydrazone (MGBG), when administered simultaneously, inhibited growth and were highly toxic to the Dunning R 3327-G hormone-resistant prostatic adenocarcinoma transplanted into Copenhagen rats. Neither DFMO (2%) nor MGBG at a nontoxic dose (15 mg/kg) inhibited tumor growth, but total (47% early cure rate) or near total suppression of growth of established tumors was observed in rats receiving both treatments.

publication date

  • January 1984

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1002/pros.2990050408

PubMed ID

  • 6429652

Additional Document Info

start page

  • 439

end page

  • 44

volume

  • 5

number

  • 4