Formation of the COOH-terminal amide group of thyrotropin-releasing-factor Academic Article uri icon

Overview

MeSH Major

  • Phospholipid Transfer Proteins

abstract

  • The precursors of peptide hormones that possess a COOH-terminal alpha-amide group contain a glycine residue following the amino acid which is amidated in the hormone. Less than Glu-His-Pro-Gly was synthesized as a putative precursor of thyroliberin. Bovine pituitary neurosecretory granules were shown to contain an amide group-forming activity associated with an Mr of about 62 000 protein(s) which converts the tetrapeptide to thyroliberin.

publication date

  • February 21, 1983

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/0014-5793(83)80395-0

Additional Document Info

start page

  • 277

end page

  • 81

volume

  • 152

number

  • 2