The Effect of Verapamil on the Lower Esophageal Sphincter Pressure in Normal Subjects and in Achalasia Academic Article Article uri icon


MeSH Major

  • Cardiovascular Diseases
  • Indians, North American


  • Verapamil hydrochloride is an organic calcium antagonist that is known to decrease the contraction of smooth muscle. The purpose of our study was to determine if verapamil has a similar effect on the resting lower esophageal sphincter pressure in normal subjects and in patients with achalasia. Esophageal manometry was performed using a continuously perfused catheter assembly. Infusion of verapamil (0.15 mg/kg) over a 2-min period resulted in a statistically significant decrease in resting lower esophageal sphincter pressure in both normal subjects (n = 8) and patients with achalasia (n = 7) within 10 min postinfusion. This study suggests that verapamil may have potential as a drug therapy in treating the clinical symptoms of achalasia and diffuse esophageal spasm.

publication date

  • January 1983



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1111/j.1572-0241.1983.tb01288.x

PubMed ID

  • 6650465

Additional Document Info

start page

  • 773

end page

  • 5


  • 78


  • 12