Transient appearance of the lupus anticoagulant in three family members sharing the A11B35DR4 haplotype Academic Article uri icon


MeSH Major

  • Blood Coagulation Disorders
  • Blood Coagulation Factors
  • Genes, MHC Class II
  • HLA Antigens
  • HLA-A Antigens


  • A prolonged partial thromboplastin time in a patient was investigated, as well as those of his family members. One sibling, the mother, and the patient all shared a lupus-like anticoagulant and low Factor XII levels in association with the A 11, Bw 35, DR 4 haplotype previously found in familial lupus erythematosis. The rest of the family had normal coagulation profiles and the entire family had normal findings when tested for ANA, complement and immune complexes. After being confirmed in a second coagulation laboratory, the lupus-like anticoagulants in the three affected members of the family disappeared upon retesting 3-8 weeks later.

publication date

  • December 1983



  • Academic Article



  • eng

PubMed ID

  • 6414325

Additional Document Info

start page

  • 275

end page

  • 8


  • 5


  • 3