Positron emission tomographic studies of aging and Alzheimer disease. Academic Article uri icon

Overview

MeSH Major

  • Aging
  • Alzheimer Disease
  • Dementia
  • Tomography, Emission-Computed

abstract

  • In this study the positron emission tomographic (PET)-18F-2-deoxy-2-fluoro-D-glucose (FDG) technique was used to study both normal aging and senile dementia. The results derived from 15 young normal subjects (mean age, 26 +/- 5 years) and 22 elderly normal subjects (mean age, 66 +/- 7 years) failed to indicate significant metabolic changes associated with age. A group of 24 patients with senile dementia (mean age, 73 +/- 7 years) showed consistent diminutions in regional glucose use relative to the elderly normals. Across all brain regions the diminutions were 17%-24%. There were also significant correlations between the measures of glucose use and the measures of cognitive functioning. Discriminant function classification analysis results indicate that better than 80% classification accuracy can be achieved for individual PET measures. These data suggest a possible future diagnostic use of PET in senile dementia.

publication date

  • May 1983

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 6410799

Additional Document Info

start page

  • 568

end page

  • 71

volume

  • 4

number

  • 3