Osteosarcoma: Intra‐arterial treatment of the primary tumor with cis‐diammine‐dichloroplatinum II (CDP): Angiographic, pathologic, and pharmacologic studies Academic Article Article uri icon


MeSH Major

  • Databases, Factual
  • Information Storage and Retrieval
  • Medicine
  • Natural Language Processing
  • Specialization
  • Vocabulary, Controlled


  • Intra-arterial CDP was utilized to treat the primary tumor in 11 pediatric patients with osteosarcoma and in one with malignant fibrous histiocytoma. The investigation commenced with a phase I-II pilot study in four osteosarcoma patients. A dose of 150 mg/m2 was found to be safe and effective in producing a clinical response. This was followed by a definitive study in the remaining seven osteosarcoma patients and in the one malignant fibrous histiocytoma patient. The results were assessed by specific clinical, pharmacologic, radiographic and pathologic criteria. The overall response in the definitive study was 50% with two patients exhibiting total tumor destruction. The success of intra-arterial CDP was attributed to its ability to achieve high local drug concentration and tumor penetration. This was demonstrated by pharmacologic studies.

publication date

  • January 1983



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1002/1097-0142(19830201)51:3<402::AID-CNCR2820510308>3.0.CO;2-P

PubMed ID

  • 6571796

Additional Document Info

start page

  • 402

end page

  • 7


  • 51


  • 3