Effects of Naloxone in Senile Dementia: A Double-Blind Trial Letter uri icon


MeSH Major

  • Alzheimer Disease
  • Dementia
  • Naloxone


  • To the Editor: Recent studies have indicated a possible modulating influence of endogenous opioid systems on memory storage.1 2 3 These effects have led some investigators to suggest that naloxone be investigated as a possible treatment for the cognitive deficits in patients with senile dementia of the Alzheimer's type.4 5 Accordingly, we conducted a preliminary, open trial of 1 mg of naloxone administered intravenously in five such patients. Clinical and psychometric indexes indicated notable improvement in three of them.6 Therefore, we conducted a double-blind, multiple-dose, placebo-controlled study of naloxone treatment in seven patients with senile dementia of the Alzheimer's type. Clinical, psychiatric, neurologic, … No extract is available for articles shorter than 400 words. © 1983, Massachusetts Medical Society. All rights reserved.

publication date

  • March 24, 1983



  • Letter



  • eng

Digital Object Identifier (DOI)

  • 10.1056/NEJM198303243081213

PubMed ID

  • 6338389

Additional Document Info

start page

  • 721

end page

  • 2


  • 308


  • 12