Immunoreactive dynorphin-(1-8) and corticotropin-releasing factor in subpopulation of hypothalamic neurons Academic Article Article uri icon


MeSH Major

  • Exons
  • Forms and Records Control
  • Mental Disorders
  • Polymorphism, Single Nucleotide


  • Immunoreactive corticotropin-releasing factor (CRF) and dynorphin-(I-8) were visualized in rat hypothalamus by immunohistofluorescence with specific antibodies. In brains from colchicine-treated, adrenalectomized rats, neuronal perikarya with immunoreactive CRF were observed in the paraventricular nucleus of the hypothalamus. The CRF occurred together with the dynorphin-(1-8). However, the CRF immunoreactivity occurred only in a subpopulation of the dynorphin-(1-8) immunoreactive cells. These findings suggest that there may be a functional interrelationship of CRF with dynorphin-related opioid peptides and provide further evidence that neurons may contain more than one bioactive substance.

publication date

  • February 14, 1983



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1126/science.6129700

PubMed ID

  • 6129700

Additional Document Info

start page

  • 189

end page

  • 91


  • 219


  • 4581