The Clinical Utility of the Dexamethasone Suppression Test in Psychiatry: Summary of a National Institute of Mental Health Workshop Academic Article uri icon


MeSH Major

  • Dexamethasone
  • Hypothalamo-Hypophyseal System
  • Mood Disorders
  • Pituitary-Adrenal System


  • The dexamethasone suppression test (DST) is being increasingly used in psychiatry, especially in the differential diagnosis of affective disorders. In light of this, the National Institute of Mental Health convened a workshop of clinical scientists drawn from neuroendocrinology, psychopathology, and general clinical psychiatry to review the evidence for the efficacy of the use of the DST in psychiatry. Specifically considered were DST's relevance to differential diagnosis, its use as a predictor of response to treatment, its relationship with other biologic variables, and technical issues. The panelists concluded that at this time there are no clear indications for routine use of the DST in diagnosis or clinical management of depression, although it is a useful research tool. Areas of potential utility include prediction of suicidal activity, prediction of relapse, and differential diagnosis.

publication date

  • October 28, 1983



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1001/jama.1983.03340160058032

PubMed ID

  • 6620522

Additional Document Info

start page

  • 2172

end page

  • 4


  • 250


  • 16