Natural history of cadaveric kidney transplants in the absence of early acute rejection Academic Article uri icon

Overview

MeSH Major

  • Graft Rejection
  • Graft Survival
  • Kidney Transplantation

abstract

  • The foremost goal in organ transplantation is to achieve normal graft function without rejection. 31 (8.7%) of 357 cadaveric kidney transplant had no evidence of rejection for the first 3 months. Among these, 2 patients died with a functioning graft and four grafts failed during the 1- to 7-year follow-up period. Actuarial graft survival rates of these patients were 96.8 and 79.0% at 2 and 5 years, respectively, as compared with 64.6 and 51.2%, respectively, for the controls (p less than 0.01). Multiple preoperative blood transfusions and the adjunctive immunosuppressive therapy with retroplacental gamma globulin appeared to be playing a role for the induction of the 'no-rejection' state. However, continuous immunosuppressive therapy is necessary to maintain graft function.

publication date

  • September 1983

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 6193438

Additional Document Info

start page

  • 6

end page

  • 10

volume

  • 35

number

  • 1