A therapeutic trial of gangliosides and thymosin in the wobbler mouse model of motor neuron disease Academic Article Article uri icon


MeSH Major

  • HIV Infections
  • Neuromuscular Diseases


  • Mixed bovine gangliosides have been reported to enhance neuronal regeneration and sprouting. The Wobbler mouse model of motor neuron disease was used to test the clinical effects of long-term ganglioside administration on the course of the disease. Mixed gangliosides were injected subcutaneously into a group of 5 Wobbler mice and compared to a control group of 5 Wobbler mice which received saline. Because of several reports implicating involvement of the immune system in ALS, a 3rd group of 5 Wobbler mice received thymosin. All mice were 4 weeks old at commencement of injections. The 3 groups were examined weekly and graded with respect to front leg power, ability to climb a vertical grating, and walking posture. After 4 months of treatment, no significant difference between either experimental group and the controls was found.

publication date

  • January 1983



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1016/0022-510X(83)90006-0

PubMed ID

  • 6644326

Additional Document Info

start page

  • 211

end page

  • 6


  • 61


  • 2