Lymphokine enhances oxygen-independent activity against intracellular pathogens Academic Article uri icon

Overview

MeSH Major

  • Lymphokines
  • Oxygen
  • Phagocytes

abstract

  • To determine if mechanisms other than the generation of toxic oxygen intermediates are active against intracellular pathogens, oxidatively deficient mouse L cells and monocyte-derived macrophages from patients with chronic granulomatous disease were stimulated with soluble lymphocyte products. Despite no enhancement in oxidative activity, these cells displayed effective microbistatic activity against both T. gondii and C. psittaci. These results suggest a potential role for nonoxidative mechanisms in the mononuclear phagocyte's activity against intracellular pathogens, and indicate that lymphokines can regulate both oxygen-dependent and oxygen-independent antimicrobial responses.

publication date

  • January 1983

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2187079

PubMed ID

  • 6864162

Additional Document Info

start page

  • 234

end page

  • 9

volume

  • 158

number

  • 1