Influence of complement depletion on sperm function in the female rabbit Academic Article uri icon

Overview

MeSH Major

  • Complement System Proteins
  • Fertilization
  • Sperm-Ovum Interactions
  • Spermatozoa

abstract

  • Female rabbits were wholly depleted of complement by treatment with anti-complementary cobra venom factor (CVF) 36 h before mating. Complement depletion did not compromise occurrence of the acrosome reaction, as judged by sperm penetration of eggs collected 12-13 h post coitum. However, in CVF-treated females, significantly more spermatozoa had penetrated the egg vestments, more spermatozoa were present in flushings from the oviducts, and sometimes the uterus, than in control females mated to the same males. The results indicate that, although the acrosome reaction is unlikely to depend on complement activation, complement-dependent factors may exert a restrictive effect on spermatozoa after vaginal insemination of the normal female rabbit.

publication date

  • January 1983

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 6631819

Additional Document Info

start page

  • 523

end page

  • 8

volume

  • 69

number

  • 2