The effect of 5-fluorouracil on DNA synthesis in the rat liver undergoing compensatory hyperplasia after partial hepatectomy
An investigation has been made into the effects of 5-fluorouracil (5FU) on DNA synthesis after partial hepatectomy. Animals underwent in vivo isolated liver perfusion with 5-fluorouracil followed by partial hepatectomy or Sham hepatectomy. Controls consisted of animals whose liver was perfused with 0.9% saline. Liver weight and DNA synthesis were recorded at various times following 5-fluorouracil perfusion and partial hepatectomy and control procedures. The results have shown that perfusion with large concentrations of the cytotoxic agent (5 FU) can be performed without apparent serious side effects on liver weight and with only minimal delay in liver cell proliferation.