Preliminary observations on the effect of recombinant leukocyte A interferon in homosexual men with Kaposi's sarcoma
Interferon Type I
Recently a syndrome of cellular immunodeficiency, susceptibility to opportunistic infection, and the development of Kaposi's sarcoma has been described, which primarily afflicts young homosexual men. Although the reasons for this outbreak are unclear, persistent cytomegalovirus infection has been considered as a possible cause of both the immunodeficiency and the sarcoma in these patients. This preliminary report describes the effect of recombinant leukocyte A interferon (IFLrA), a purified human interferon produced by recombinant-DNA techniques, on tumor growth and immune function in 13 patients treated during the course of a Phase I trial of this agent. Of 12 evaluable patients, 5 had major objective responses (3 complete and 2 partial), and 3 others had minor temporary responses. Our data suggest that interferon may prove to be useful in the treatment of Kaposi's sarcoma in immunosuppressed patients.