Anti-MAG IgM antibodies in patients with neuropathy and IgM M proteins: Detection by ELISA Academic Article uri icon

Overview

MeSH Major

  • Antibodies, Anti-Idiotypic
  • Demyelinating Diseases
  • Immunoglobulin M
  • Myelin Proteins

abstract

  • In some patients with plasma cell dyscrasia and neuropathy, there are IgM M proteins that react with the myelin-associated glycoprotein (MAG). We used an enzyme-linked immunosorbent assay (ELISA) system to detect anti-MAG IgM antibodies. Reactivity with human MAG by ELISA correlated with demonstration of anti-MAG IgM antibodies by the "immunoblot" technique. Human MAG was more effective than bovine MAG as antigen, and there was no significant reactivity with mouse MAG. The ELISA system is a simple and convenient method for detecting anti-MAG IgM antibodies.

publication date

  • August 25, 1983

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 6191246

Additional Document Info

start page

  • 939

end page

  • 42

volume

  • 33

number

  • 7