Haemodynamic and metabolic effects on dazoxiben at rest and during atrial pacing Academic Article uri icon

Overview

MeSH Major

  • Cardiac Pacing, Artificial
  • Hemodynamics
  • Imidazoles
  • Myocardium
  • Oxidoreductases
  • Thromboxane-A Synthase

abstract

  • 1 Thromboxane B2 (TXB2) levels were measured in three sites (coronary sinus, pulmonary artery, and femoral artery) at rest and during atrial pacing in 11 patients with stable angina pectoris. 2 There was a highly significant increase in arterial TXB2 on pacing (by up to 820 pg/ml) but there was no change in the thromboxane levels at the other two sites. 3 Dazoxiben 200 mg orally abolished the increase in arterial TXB2, but had no effect on systemic, pulmonary or coronary haemodynamics, no effect on myocardial metabolism and a variable effect on atrial pacing time to angina.

publication date

  • July 14, 1983

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC1427677

PubMed ID

  • 6681708

Additional Document Info

start page

  • 73S

end page

  • 77S

volume

  • 15

number

  • Suppl. 1